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Quantitative 3D In Silico Modeling (q3DISM) of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer’s Disease
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JoVE Journal Medicina
Quantitative 3D In Silico Modeling (q3DISM) of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer’s Disease

Quantitative 3D In Silico Modeling (q3DISM) of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer’s Disease

DOI:
10.3791/54868-v

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09:33 min

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December 26, 2016

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, ,
1Zilkha Neurogenetic Institute,University of Southern California (USC)

Capitoli

  • 00:05Titolo
  • 01:12Immunostaining
  • 02:51Large Z-stack Confocal Dataset-acquisition and Quantitative 3D In Silico Modeling (q3DISM)
  • 07:28Results: Representative Visualization and Quantitation of Amyloid-beta Phagocytosis in Rodent Brains
  • 08:39Conclusion

Summary

Traduzione automatica

Traduzione automatica

We developed a methodology for quantitative 3D in silico modeling (q3DISM) of cerebral amyloid-β (Aβ) phagocytosis by mononuclear phagocytes in rodent models of Alzheimer's disease. This method can be generalized for the quantitation of virtually any phagocytic event in vivo.

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Keywords: Quantitative 3D In Silico ModelingQ3DISMAmyloid-beta PhagocytosisAlzheimer’s DiseaseRodent ModelsMacrophageImmunostainingConfocal Microscopy

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