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定量3D<em>在硅片</em>建模阿尔茨海默病的啮齿动物模型脑淀粉样蛋白-β吞噬（q3DISM）
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Medicina
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JoVE Journal Medicina
Quantitative 3D In Silico Modeling (q3DISM) of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer’s Disease
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定量3D<em>在硅片</em>建模阿尔茨海默病的啮齿动物模型脑淀粉样蛋白-β吞噬（q3DISM）

DOI:
10.3791/54868-v

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09:33 min

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December 26, 2016

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, ,
1Zilkha Neurogenetic Institute,University of Southern California (USC)

Capitoli

  • 00:05Titolo
  • 01:12Immunostaining
  • 02:51Large Z-stack Confocal Dataset-acquisition and Quantitative 3D In Silico Modeling (q3DISM)
  • 07:28Results: Representative Visualization and Quantitation of Amyloid-beta Phagocytosis in Rodent Brains
  • 08:39Conclusion

Summary

Traduzione automatica

Traduzione automatica

我们开发了在硅片建模（q3DISM）脑淀粉样蛋白β（Aβ）吞噬在阿尔茨海默氏病的啮齿动物模型单核吞噬细胞的定量三维的方法。该方法可推广用于体内几乎任何吞噬活动的定量。

Tags

Quantitative 3D In Silico ModelingQ3DISMAmyloid-beta PhagocytosisAlzheimer’s DiseaseRodent ModelsMacrophageImmunostainingConfocal Microscopy

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