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O Colon-26 Carcinoma Tumor-rolamento Mouse como um modelo para o estudo do câncer caquexia
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Capitoli
- 00:05Titolo
- 00:58Tumor Cell Implantation and Blood Collection
- 02:05Tissue and Organ Excision
- 04:04Muscle Freezing, Mounting, and Sectioning
- 05:57Results: Representative Muscle Growth Analyses in C26 Tumor-bearing Mice
- 07:33Conclusion
Mice bearing the Colon-26 (C26) carcinoma represent a classical model of cancer cachexia. Progressive muscle wasting occurs in association with tumor growth, over-expression of muscle-specific ubiquitin ligases, and reductions in muscle cross-sectional area. Fat loss is also observed. Cachexia is studied in a time-dependent manner with increasing severity of wasting.
