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Hipoparatiroid Fare oluşturma iki Teknikleri: Paratiroidektomi GFP Rakorlar ve Difteri-Toksin-Aracılı Paratiroid Ablasyonu kullanma
JoVE Journal
Medicina
This content is Free Access.
JoVE Journal Medicina
Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
DOI:

07:13 min

March 14, 2017

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Capitoli

  • 00:05Titolo
  • 01:18Parathyroidectomy Using GFP Glands
  • 04:08Diphtheria-Toxin-Mediated Parathyroid Ablation
  • 04:50Results: Phenotypes of 2 Acquired Hypoparathyroidism Mouse Models
  • 06:16Conclusion

Summary

Traduzione automatica

Mice with acquired hypoparathyroidism would be useful for studying novel drug therapies for hypoparathyroidism. Two procedures to create such mice are demonstrated. The GFP-PTX mouse is generated by surgical parathyroidectomy guided by green fluorescing parathyroid glands. A second, non-surgical approach is based on parathyroid-specific expression of the diphtheria toxin receptor.

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