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Solvent Bonding for Fabrication of PMMA and COP Microfluidic Devices
 

Solvent Bonding for Fabrication of PMMA and COP Microfluidic Devices

Article DOI: 10.3791/55175-v • 04:54 min • January 17th, 2017
January 17th, 2017 •
1, 1,2, 1,2
1Department of Mechanical & Industrial Engineering, University of Toronto, 2Institute of Biomaterials and Biomedical Engineering (IBBME), University of Toronto

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Solvent bonding is a simple and versatile method for fabricating thermoplastic microfluidic devices with high quality bonds. We describe a protocol to achieve strong, optically clear bonds in PMMA and COP microfluidic devices that preserve microfeature details, by a judicious combination of pressure, temperature, an appropriate solvent, and device geometry.

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Keywords: Solvent Bonding PMMA COP Microfluidic Devices Thermoplastic Device Fabrication Microfluidic Cell Culture Point-of-care Diagnostics Layer Bonding Visual Inspection Solvent Application Bubble Removal Layer Alignment Heated Press
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