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Använda Zebrafish Modeller av mänsklig influensa A-virus infektioner till skärm antivirala läkemedel och karakterisera värdens immuncellsvar
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1Department of Molecular and Biomedical Sciences,University of Maine, 2Graduate School of Biomedical Sciences and Engineering,University of Maine, 3School of Biology and Ecology,University of Maine, 4Division of Intramural Research, Immunity, Inflammation and Disease Laboratory,National Institute of Environmental Health Sciences, NIH, 5Department of Chemical and Biological Engineering,University of Maine
Capitoli
- 00:05Titolo
- 00:44Systemic Influenza A Virus Infection at 48 Hr Post Fertilization
- 03:07Localized, Swim Bladder IAV Infection of Tg(mpx:mCherry) Transgenic Zebrafish
- 04:19Anti-viral Drug Treatment
- 05:23Mounting Zebrafish for Imaging
- 06:39Results: Anti-viral Drug Treatment of IAV Infection in Zebrafish
- 08:25Conclusion
Systemic and localized zebrafish infection models for human influenza A virus are demonstrated. Using a systemic infection model, zebrafish can be used to screen antiviral drugs. Using a localized infection model, zebrafish can be used to characterize host immune cell responses.
