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태아 알코올 스펙트럼 장애의 쥐 모델에서 Hippocampal 기능 장애를 평가 하기 위해 추적 Eyeblink 클래식 컨디셔닝의 사용
JoVE Journal
Neuroscienze
Author Produced
This content is Free Access.
JoVE Journal Neuroscienze
The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
DOI:

19:57 min

August 05, 2017

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Capitoli

  • 00:00Titolo
  • 01:02Neonatal Alcohol Exposure
  • 02:53Eyelid Surgery
  • 02:56Eyelid Surgery: Materials and Setup
  • 03:13Eyelid Surgery: Animal Preparation
  • 03:50Eyelid Surgery: Surgery
  • 09:34Trace Eyeblink Classical Conditioning
  • 09:37Trace Eyeblink Classical Conditioning: Animal Preparation and System Setup
  • 10:40Trace Eyeblink Classical Conditioning: Animal Status Check
  • 11:08Trace Eyeblink Classical Conditioning: Explantation of Trace ECC Procedure
  • 15:00Trace Eyeblink Classical Conditioning: Software Setup and Begin Testing
  • 15:44Trace Eyeblink Classical Conditioning: Live Recording: Unintubated-control Rat Session 1 Trial 15
  • 15:57Trace Eyeblink Classical Conditioning: Replay at 0.30x Speed
  • 16:14Trace Eyeblink Classical Conditioning: Progression of Training Through Six Sessions
  • 16:36Trace Eyeblink Classical Conditioning: Development of Adaptive CRs
  • 16:46Trace Eyeblink Classical Conditioning: Live Recording: Unintubated-control Rat Session 6 Trial 96
  • 16:58Trace Eyeblink Classical Conditioning: Replay at 0.30x Speed
  • 17:18Trace Eyeblink Classical Conditioning: Live Recording: Alcohol-intubated-control Rat Session 6 Trial 100
  • 17:35Representative Results
  • 19:00Conclusion

Summary

Traduzione automatica

추적 eyeblink 클래식 컨디셔닝 (ECC) 평가 하는 데 사용 되었다 hippocampal 종속 연관 학습 했다 성인 쥐에 투여 초기 신생아 두뇌 개발 하는 동안 알코올의 높은 농도 (11.9 %v / v). 일반적으로, ECC 절차는 많은 심리적, 생물 의학 설정을 통해 뇌 기능 장애를 탐지 하기 위한 사운드 진단 도구입니다.

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