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IPSC 파생 된 인간의 두뇌 Organoids의 세대는 초기 신경 발달 장애를 모델링하기
JoVE Journal
Biologia dello sviluppo
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JoVE Journal Biologia dello sviluppo
Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders
DOI:

07:40 min

April 14, 2017

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Capitoli

  • 00:05Titolo
  • 00:49Embedding Neurospheres in EHS Matrix
  • 01:57Organoids in a Rotary Suspension Culture
  • 03:08Analysis of Brain Organoids
  • 05:47Results: Immunofluorescent Imaging of Cryosectioned Organoids
  • 06:48Conclusion

Summary

Traduzione automatica

Modeling human brain development has been hindered due to the unprecedented complexity of neural epithelial tissue. Here, a method for the robust generation of brain organoids to delineate early events of human brain development and to model microcephaly in vitro is described.

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