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A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
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Biologia
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JoVE Journal Biologia
A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

DOI:
10.3791/55825-v

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07:52 min

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November 07, 2017

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, , , , ,
1Marshall Institute for Interdisciplinary Research (MIIR),Marshall University, 2Department of Biomedical Sciences,Marshall University Joan C. Edwards School of Medicine

Capitoli

  • 00:05Titolo
  • 01:00Left Kidney Pole Ligation
  • 03:50Right Kidney Removal
  • 05:09Results: Representative Effects of Left Kidney Polar Ligation
  • 06:39Conclusion

Summary

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This manuscript provides a detailed two-step surgical procedure to perform mouse 5/6th partial nephrectomy (PNx) with pole ligation. Four weeks after surgery, in comparison with sham-operated mice, the PNx mice developed impaired renal function, anemia, cardiac hypertrophy, cardiac fibrosis, and decreased heart systolic and diastolic function.

Tags

Artificial Kidney Disease ModelMouse 5/6th NephrectomyUremic CardiomyopathyChronic Kidney DiseasePartial NephrectomyKidney LigationExperimental Renal Disease Model

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