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在小鼠模型中将胶质母细胞瘤治疗干细胞的鼻内递送
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JoVE Journal Medicina
Intranasal Delivery of Therapeutic Stem Cells to Glioblastoma in a Mouse Model
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在小鼠模型中将胶质母细胞瘤治疗干细胞的鼻内递送

DOI:
10.3791/55845-v

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09:57 min

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June 04, 2017

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, , ,
1Department of Neurological Surgery, Feinberg School of Medicine,Northwestern University

Capitoli

  • 00:05Titolo
  • 01:04Intracranial Implantantion and Whole Brain Irradiation
  • 04:16Human Neural Stem Cell (NSC) Modification and Intranasal Delivery
  • 07:14Results: Representative hNSC Modifications and Analyses
  • 08:53Conclusion

Summary

Traduzione automatica

Traduzione automatica

干细胞是有希望的治疗载体，以治疗脑肿瘤由于其内在的肿瘤向性。非侵入性鼻内干细胞传播绕过血脑屏障，并且具有很强的临床翻译潜力。本文概述了胶质瘤小鼠模型中鼻内干细胞传递的基本原理。

Tags

Keywords: Intranasal DeliveryTherapeutic Stem CellsGlioblastomaMouse ModelPreclinicalBrain TumorBlood-brain BarrierBrain MalignanciesBrain DisordersGlioma CellsCell CultureTrypsinPBSCell SuspensionCentrifugationSterile SalineStereotaxic FrameHamilton Micro-syringeBurr HoleDura Surface

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