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Tumor Engraftment i en Xenograft musemodel af menneskelige Mantle celle lymfom
JoVE Journal
Ricerca sul cancro
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JoVE Journal Ricerca sul cancro
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
DOI:

10:52 min

March 30, 2018

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Capitoli

  • 00:05Titolo
  • 01:23Preparation of Primary Peripheral Blood Mononuclear Cells by Density Gradient Separation
  • 03:15Enrichment of B Cells Negative Selection
  • 05:34Development of the Xenograft Mouse Model
  • 06:07Chimerism Analysis of Tumor Cell Engrafted in Different Organs
  • 07:43Results: Use of Flow Cytometry to Analyze the B Cell Enrichment in Mice Xenografts Obtained from Mantle Cell Lymphoma Patients
  • 09:08Conclusion

Summary

Traduzione automatica

Mantle celle lymfom (MCL) er en vanskelig at behandle B-celle sygdom og det er lige så vanskeligt at etablere en xenograft musemodel af primære MCL at studere og udvikle therapeutics. Her beskriver vi vellykket etablering af MCL xenografts i mus til at hjælpe med at forstå dens underliggende biologi.

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