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Bioengineering

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JoVE Journal Bioengineering
DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers
 

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers

Article DOI: 10.3791/56056-v • 08:00 min • October 25th, 2017
October 25th, 2017 •
*1,2, *1,2, 1, 1,2, 1, 1, 1,2, 2, 1
1Fraunhofer Institute for Cell Therapy and Immunology, 2Institute of Experimental Physics I, Universität Leipzig
* These authors contributed equally

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Semiflexible polymers display unique mechanical properties that are extensively applied by living systems. However, systematic studies on biopolymers are limited since properties such as polymer rigidity are inaccessible. This manuscript describes how this limitation is circumvented by programmable DNA nanotubes, enabling experimental studies on the impact of filament rigidity.

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DNA Nanotubes Versatile Tool Study Semiflexible Polymers DNA-based Model System Fundamental Properties Biopolymers Soft Metaphysics Semiflexible Filaments Networks Mechanical Properties Intravisive Filaments Tunable Experimental Systems Hydrogel Cell Migration Matrices Unit Ring Unit Rings Stack Elongated Nanotubes Re-suspend Lyophilized Oligonucleotides Purified Water Concentration Micromolar
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