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Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap
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Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap

Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap

DOI:
10.3791/56077-v

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08:05 min

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November 03, 2017

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, , ,
1The Miami Project to Cure Paralysis,University of Miami Miller School of Medicine, 2Department of Materials Science and Engineering,New Jersey Institute of Technology, 3Department of Biomedical Engineering,New Jersey Institute of Technology, 4Department of Cell Biology,University of Miami Miller School of Medicine, 5Department of Neurological Surgery,University of Miami Miller School of Medicine

Capitoli

  • 00:05Titolo
  • 01:19Complete Transection at Thoracic Level 8 (T8)
  • 03:47Transection at T8, Conduit Insertion, and Schwann Cell/Matrix Injection
  • 06:36Results: Representative Transplanted Spinal Cord Section Images
  • 07:15Conclusion

Summary

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This article describes a technique to insert a hollow conduit between the spinal cord stumps after complete transection and fill with Schwann cells (SCs) and injectable basement membrane matrix in order to bridge and promote axon regeneration across the gap.

Tags

Schwann CellsPVDF-TrFE ConduitsSpinal Cord TransectionAxon RegenerationLaminectomyRat ModelSurgical Procedure

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