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Journal / Genetics / Expedited Radiation Biodosimetry by Automated…
JoVE Journal
Genetics

This Contenuto is Open Access.

JoVE Journal Genetics
Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation
 

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation

Article DOI: 10.3791/56245-v • 10:33 min • September 4th, 2017
September 4th, 2017 •
*1, *1, 1,2, 1,3
1CytoGnomix Inc., 2Department of Pathology and Laboratory Medicine, Western University, 3Department of Biochemistry, Western University
* These authors contributed equally

Capitoli

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The cytogenetic dicentric chromosome (DC) assay quantifies exposure to ionizing radiation. The Automated Dicentric Chromosome Identifier and Dose Estimator software accurately and rapidly estimates biological dose from DCs in metaphase cells. It distinguishes monocentric chromosomes and other objects from DCs, and estimates biological radiation dose from the frequency of DCs.

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Keywords: Radiation Biodosimetry Dicentric Chromosome Identification Automated Image Processing Radiation Dose Estimation Machine Learning Cytogenetic Analysis Metaphase Chromosome Images Radiation Exposure Calibration Curve Sample Processing Image Filtering Genetic Disease Diagnosis
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