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Journal / Biochemistry / Single-molecule Manipulation of G-quadruplexes by …
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Biochemistry

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JoVE Journal Biochemistry
Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers
 

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers

Article DOI: 10.3791/56328-v • 08:28 min • September 19th, 2017
September 19th, 2017 •
*1, *2,3, 2,4, 1, 2,4,5
1School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, 2Mechanobiology Institute, National University of Singapore, 3Department of Physics, National University of Singapore, 4Research Institute for Biomimetics and Soft Matter, Fujian Provincial Key Lab for Soft Functional Materials Research, Department of Physics, Xiamen University, 5Center for Bioimaging Sciences, National University of Singapore
* These authors contributed equally

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A single-molecule magnetic tweezers platform to manipulate G-quadruplexes is reported, which allows for the study of G4 stability and regulation by various proteins.

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Single-molecule Manipulation G-quadruplexes Magnetic Tweezers Folding And Unfolding Binding Proteins Nanometer-sized Floating Dynamics Anti-drift Technique G4 Stability Helicase Activities Al-a-do-gees Therapeutic Applications Protein-DNA Interactions Protein-protein Interactions G4 DNA Preparation Ligate G4 Forming Single Stranded DNA Flank Single Stranded DNA Double Stranded DNA Handle T4 DNA Ligase Magnetic Tweezers Setup Lab View Program
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