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Cancer Research

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JoVE Journal Cancer Research
PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
 

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Article DOI: 10.3791/56601-v • 10:48 min • December 28th, 2017
December 28th, 2017 •
1, 2, 3, 2, 1
1Department of Nuclear Medicine, Ghent University Hospital, 2IBiTech-MEDISIP, Department of Electronics and Information Systems, Ghent University, 3Department of Radiation Oncology, Ghent University Hospital

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In the past, small animal irradiation was usually performed without the ability to target a well-delineated tumor volume. The goal was to mimic the treatment of human glioblastoma in rats. Using a small animal irradiation platform, we performed MRI-guided 3D conformal irradiation with PET-based sub-volume boosting in a preclinical setting.

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Keywords: PET MRI Glioblastoma Rat Model Micro-irradiator Image-guided Conformal Irradiation Radiation Therapy Tumor Volume Cancer Biology Stereotactic Inoculation MRI Scan Contrast Agent
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