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后半圆管法在新生小鼠内耳基因传递中的研究

JoVE Journal
Medicina

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JoVE Journal Medicina

Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse

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后半圆管法在新生小鼠内耳基因传递中的研究

DOI:

10.3791/56648-v

•

03:52 min

•

March 02, 2018

•

Kevin Isgrig, Wade W. Chien²

¹National Institute on Deafness and Other Communication Disorders,National Institutes of Health, ²Department of Otolaryngology-Head & Neck Surgery,Johns Hopkins School of Medicine

Capitoli

00:05Titolo
00:32Procedure Setup
01:08Surgical Approach
02:35Results: Transduction of Utricular and Cochlear Hair Cells
03:22Conclusion

Summary

Traduzione automatica

在本研究中, 我们描述了后半圆管方法作为一种可靠的方法, 为内耳基因分娩的新生小鼠。我们表明, 通过后半规管的基因传递能够灌注整个内耳。

Tags

Posterior Semicircular Canal Inner Ear Gene Delivery Neonatal Mouse AAV8-whirlin Gene Therapy Hair Cell Transduction Stereocilia Elongation Surgical Dissection Micro-injection

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