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Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery
JoVE Journal
Bioingegneria
This content is Free Access.
JoVE Journal Bioingegneria
Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery
DOI:

10:38 min

January 15, 2018

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Capitoli

  • 00:05Titolo
  • 00:38Synthesis of Polyethylene Glycol-coated Gold Nanoparticles (PEG-AuNPs)
  • 03:13Conjugation of Fluorophores onto the PEG-AuNP NH2 Groups
  • 04:56Characterization of Fluorescent PEG-AuNPs
  • 08:46Results: Size and Biocompatibility of THPC-coated and Fluorescent PEG-AuNPs
  • 10:19Conclusion

Summary

Traduzione automatica

We describe a method of synthesizing biocompatible 10-nm gold nanoparticles, functionalized by coating poly-ethylene glycol onto the surface. These particles can be used in vitro and in vivo for delivering therapeutics to nanoscale cellular and extracellular spaces that are difficult to access with conventional nanoparticle sizes.

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