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Improvement of a Closed Chest Porcine Myocardial Infarction Model by Standardization of Tissue and Blood Sampling Procedures
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JoVE Journal Medicina
Improvement of a Closed Chest Porcine Myocardial Infarction Model by Standardization of Tissue and Blood Sampling Procedures

Improvement of a Closed Chest Porcine Myocardial Infarction Model by Standardization of Tissue and Blood Sampling Procedures

DOI:
10.3791/56856-v

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10:01 min

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March 12, 2018

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, , , ,
1Department for Biomedical Research,University of Bern, 2Graduate School for Cellular and Biomedical Sciences,University of Bern, 3Institute of Chemical Sciences and Engineering,Ecole Polytechnique Fédérale de Lausanne (EPFL)

Capitoli

  • 00:04Titolo
  • 00:43Anesthesia and Preparation of the Animal
  • 06:07Sampling the Heart
  • 08:05Results: Treatment with FXIIa Inhibitor
  • 09:05Conclusion

Summary

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Here we demonstrate a protocol to standardize sampling procedures of an established porcine model of acute myocardial infarction in order to increase its translational value in the understanding of the pathophysiology of myocardial ischemia/reperfusion injury and to test novel drug candidates.

Tags

PorcineMyocardial InfarctionClosed ChestBlood SamplingIschemia Reperfusion InjuryAngiographyCatheterizationLeft VentricleCoronary ArteryContrast MediumBlood CollectionCentrifugation

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