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化学共轭法在戊型肝炎病毒纳米粒子表面功能化中的应用
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Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods
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化学共轭法在戊型肝炎病毒纳米粒子表面功能化中的应用

DOI:
10.3791/57020-v

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09:12 min

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May 11, 2018

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, , ,
1Department of Molecular and Cellular Biology,University of California Davis

Capitoli

  • 00:04Titolo
  • 00:50HEVNP Characterization
  • 02:46Chemical Conjugation of HEVNPs with Biotin, Cancer Targeting Ligand, and Fluorophores
  • 07:05Results: Production of LXY30-HEVNPs and Binding/Internalization of Fluorescently Labeled LXY30-HEVNPs in MDA-MB-231 Breast Cancer Cells
  • 08:35Conclusion

Summary

Traduzione automatica

Traduzione automatica

我们已将戊型肝炎病毒的衣壳蛋白作为 theranostic 纳米微粒 (HEVNP) 进行了设计。HEVNP 自组装成一个稳定的 icosahedral 笼在黏膜分娩。在这里, 我们描述了 HEVNPs 的改变的肿瘤靶向性的变异表面暴露残留到半胱氨酸, 共轭合成配体, 具体绑定肿瘤细胞。

Tags

Keywords: HEV NanoparticlesSurface FunctionalizationChemical ConjugationTargetingDiagnosisTreatmentNano TherapeuticsTEM ImagingMaleimide-linked BiotinDialysis

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