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Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
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JoVE Journal Chimica
Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation

DOI:
10.3791/57356-v

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11:09 min

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August 01, 2018

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, , ,
1Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology,Peking University Shenzhen Graduate School

Capitoli

  • 00:04Titolo
  • 00:38Manual Solid-Phase Peptide Synthesis
  • 02:42Formation of Thioether Linker by On-Resin Cyclization
  • 05:29Thioether Linker Formation via Intermolecular Thio-ene Reaction and Peptide Cyclization via Macrolactamization
  • 07:02Solution-Phase Formation of a Vinyl Sulfide Linker
  • 08:41Results: Thioether- and Vinyl Sulfide-Tethered Cyclic Peptides
  • 10:42Conclusion

Summary

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We present a protocol for the construction of thioether/vinyl sulfide-tethered helical peptides using photo-induced thiol-ene/thiol-yne hydrothiolation.

Tags

ThioetherVinyl SulfideHelical PeptidesPhoto-induced Thiol-ene/yne Hydro-thiolationRink Amide MBHA ResinFmoc DeprotectionHCTUDIPEATrityl DeprotectionSolid-phase Peptide Synthesis

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