Rivista
/
Medicina
/
A Closed-chest Model to Induce Transverse Aortic Constriction in Mice
JoVE Journal
Medicina
È necessario avere un abbonamento a JoVE per visualizzare questo.  Accedi o inizia la tua prova gratuita.
JoVE Journal Medicina
A Closed-chest Model to Induce Transverse Aortic Constriction in Mice

A Closed-chest Model to Induce Transverse Aortic Constriction in Mice

DOI:
10.3791/57397-v

•

08:10 min

•

April 05, 2018

•

, , , , , , ,
1Department of Anaesthesiology,University Hospital Bonn, 2Department of Cardiac Surgery,University Hospital Bonn, 3Institute of Physiology 2,University of Bonn, 4Department of Medicine – Cardiology,University Hospital Bonn

Capitoli

  • 00:04Titolo
  • 01:01Induction of Anesthesia and Intubation
  • 02:57Preoperative Doppler Measurement and Thoracotomy
  • 04:03Banding the Transverse Aorta
  • 05:58Results: Induction of Successful Transverse Aortic Constriction in Mice
  • 07:30Conclusion

Summary

Traduzione automatica

Traduzione automatica

Here, we present a protocol of Transverse Aortic constriction (TAC) via a lateral thoracotomy. This technique is a minimally invasive, closed chest surgical procedure aiming to simulate pressure overload and heart failure in mice utilizing standard TAC laboratory settings.

Tags

Transverse Aortic ConstrictionMurine Closed Chest ModelLeft Ventricular Myocardial HypertrophyMinimal Invasive TechniqueCardiac MacrophagiaRib CageSurgical TraumaAnesthesiaIntubationCarotid ArteriesDoppler Probe

Article

Embed

AGGIUNGI ALLA PLAYLIST

Usage Statistics

Video correlati

check_url/it/57397?article_type=v

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
check_url/it/57397?article_type=v

A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion
check_url/it/57397?article_type=v

Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy Model
check_url/it/57397?article_type=v

A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique
check_url/it/57397?article_type=v

A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice
check_url/it/57397?article_type=v

Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging
check_url/it/57397?article_type=v

Minimally Invasive Transverse Aortic Constriction in Mice
check_url/it/57397?article_type=v

Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy
check_url/it/57397?article_type=v

Improvement of a Closed Chest Porcine Myocardial Infarction Model by Standardization of Tissue and Blood Sampling Procedures
check_url/it/57397?article_type=v

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Read Article