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球体、菌落形成测定和斑马鱼移植对抗癌香豆素 OT48 生物活性的临床前评价
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Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
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球体、菌落形成测定和斑马鱼移植对抗癌香豆素 OT48 生物活性的临床前评价

DOI:
10.3791/57490-v

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09:20 min

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June 26, 2018

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, ,
1Department of Pharmacy, College of Pharmacy,Seoul National University

Capitoli

  • 00:04Titolo
  • 00:33Colony Formation Assays
  • 03:47Zebrafish Egg Production and Incubation for Xenograft Assay
  • 05:05Compound-treated Cell Preparation and Microinjection of Cancer Cells for Xenograft Formation
  • 07:21Results: Inhibitory Potential of Anticancer Compounds on Spheroid Formation and In Vivo Tumor Formation in Zebrafish
  • 08:29Conclusion

Summary

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在这里, 我们提出了应用3D 培养和斑马鱼的抗癌香豆素的临床前筛选。

Tags

Preclinical AssessmentBioactivityAnticancer Coumarin OT48SpheroidsColony Formation AssaysZebrafish XenograftsIn VitroIn Vivo3D Culture SystemsA549 CellsRPMI 1640 MediumMethylcellulose-based MediumMTT AssayImageJ SoftwareDrug Discovery

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