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Developmental Biology

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JoVE Journal Developmental Biology
Eine familiäre Hypercholesterinämie menschlichen Leber chimärer Maus-Modell mit induzierten pluripotenten Stammzellen gewonnenen Hepatozyten
 
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Eine familiäre Hypercholesterinämie menschlichen Leber chimärer Maus-Modell mit induzierten pluripotenten Stammzellen gewonnenen Hepatozyten

Article DOI: 10.3791/57556-v • 10:56 min • September 15th, 2018
September 15th, 2018 •
*1,2,6, *2, *3, 1,2, 2, 2, 4,5, 4,5, 2, 4,5, 4,5, 4,5, 4,5, 3, 4,5,7, 1,2,6,7
1Department of Medicine, University of Hong Kong-Shenzhen Hospital, 2The Cardiology Division, Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, 3School of Biomedical Sciences, Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, 4Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical University, 5Laboratory of RNA, Chromatin, and Human Disease, CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 6Research Centre of Heart, Brain, Hormone, and Healthy Ageing, Li Ka Shing Faculty of Medicine, University of Hong Kong, 7Hong Kong-Guangdong Stem Cell and Regenerative Medicine Research Centre, University of Hong Kong and Guangzhou Institutes of Biomedicine and Health
* These authors contributed equally

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Hier präsentieren wir ein Protokoll, um eine menschliche Leber chimärer Maus-Modell der Familiäre Hypercholesterinämie mit menschlichen induzierten pluripotenten Stammzellen gewonnenen Hepatozyten zu generieren. Dies ist ein wertvolles Modell zum Testen neuer Therapien für Hypercholesterinämie.

Tags

Ausgabe 139 familiär Hypercholesterinämie Hepatozyten Entwicklungsbiologie menschlichen Leber chimeric Mäuse induzierte pluripotente Stammzellen LDL-Rezeptor Statine PCSK9 Antikörper
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