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nog 小鼠多发性骨髓瘤异种移植的多模态生物发光和正电子发射成形断层扫描成像
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Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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nog 小鼠多发性骨髓瘤异种移植的多模态生物发光和正电子发射成形断层扫描成像

DOI:
10.3791/58056-v

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05:32 min

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January 07, 2019

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, , , , , , ,
1Greater Los Angeles Veteran Administration Healthcare System, 2San Diego Veterans Administration Healthcare System, 3University of California, Los Angeles, 4Perkin Elmer

Capitoli

  • 00:04Titolo
  • 00:348226 LUC Engraftment and In Vivo Bioluminescence Monitoring
  • 01:58Targeted Therapy and Tumor Metabolism Monitoring
  • 03:49Results: Representative Multimodal Multiple Myeloma Bone Marrow Xenograft Monitoring
  • 04:53Conclusion

Summary

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在这里, 我们使用生物发光, x 射线和正电子发射断层扫描断层扫描断层扫描成像, 以研究如何抑制 mtor 活性影响骨骨髓移植骨髓瘤肿瘤在异种移植模型。这使得生理相关, 非侵入性, 多模态分析的抗骨髓瘤的作用治疗针对骨髓移植骨髓瘤肿瘤在体内。

Tags

Multimodal ImagingBioluminescencePositron Emission TomographyComputational TomographyMultiple MyelomaBone MarrowXenograftsNOG MiceAnti-drug StudiesBiochemical Pathways8226 LuciferaseD-luciferinTemsirolimusFludeoxyglucoseRadiolabeled Probe

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