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Isometric Contractility Measurement of the Mouse Mesenteric Artery Using Wire Myography
 

Isometric Contractility Measurement of the Mouse Mesenteric Artery Using Wire Myography

Article DOI: 10.3791/58064-v • 09:42 min • August 20th, 2018
August 20th, 2018 •
1, 2, 1, 1, 2, 1
1Model Animal Research Center and MOE Key Laboratory of Model Animal and Disease Study, Nanjing University, 2School of Pharmacy, Nanjing University of Chinese Medicine

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The wire myograph technique is used to investigate vascular smooth muscle functions and screen new drugs. We report a detailed protocol for measuring the isometric contractility of the mouse mesenteric artery and for screening new relaxants of vascular smooth muscle.

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Keywords: Isometric Contractility Wire Myography Mesenteric Artery Vascular Smooth Muscle Contractility Measurement Hypertension Therapy High Potassium Multi-channel System Drug Screening Euthanized Mouse Gastrointestinal Tract Mesenteric Artery Dissection HEPES-Tyrode Solution Stereoscopic Microscope Connective Tissue Calcium-free Solution Artery Segment Stainless Steel Wire
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