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Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice
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JoVE Journal Neuroscienze
Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice

Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice

DOI:
10.3791/58073-v

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09:06 min

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January 09, 2019

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, ,
1Hearing Systems Group, Department of Electrical Engineering,Technical University of Denmark, 2Brain and Sound Lab, Department of Biomedicine,Basel University

Capitoli

  • 00:04Titolo
  • 00:41Pre-deafening Acoustic Auditory Brainstem Response (aABR)
  • 02:37Deafening Surgery
  • 05:50Cochlear Implant Electrode Array Insertion and Electric ABR (eABR)
  • 07:22Results: Representative eABR Analysis
  • 08:22Conclusion

Summary

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Animal models of cochlear implants can advance knowledge of the technological bases of treating permanent sensorineural hearing loss with electrical stimulation. This study presents a surgical protocol for acute deafening and cochlear implantation of an electrode array in mice as well as the functional assessment with auditory brainstem response.

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Keywords: Cochlear ImplantAuditory Brainstem ResponseC57BL/6 MiceDeafeningCochlear ImplantationAcute DeafeningFunctional AssessmentCochlear Implant SurgeryAuditory Brain Stem ResponseHearing LossElectric StimulationAnimal ModelStapedial ArteryRound Window NicheClick StimulusAVR Threshold

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