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用于靶向质粒DNA输送的美聚氨酸功能化生物相容性块共聚物

JoVE Journal
Chimica

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JoVE Journal Chimica

Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery

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用于靶向质粒DNA输送的美聚氨酸功能化生物相容性块共聚物

DOI:

10.3791/58527-v

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08:09 min

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August 06, 2019

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Yang Wu*¹, Wei Zhang*², Jian Zhang, Zhi-Xiang Mao, Li Ding, Hao Li, Rong Ma, Jin-Hai Tang

¹Research Center of Clinical Oncology,Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & Nanjing Medical University Affiliated Cancer Hospital, ²Department of General Surgery,The First Affiliated Hospital with Nanjing Medical University, ³School of Clinical Medicine,Xuzhou Medical University

Capitoli

00:04Titolo
01:09Synthesis of BNHEMA Polymer (PBNHEMA)
03:21Synthesis of BNHEMA-b-APMA polymer (BA)
04:18Transfection Efficiency of mBG/ GFP-pDNA Polyplexes
05:10Results: Analysis of the Targeted Plasma DNA Delivery
07:11Conclusion

Summary

Traduzione automatica

本作品通过可逆添加-碎片链转移(RAFT)方法介绍了蛋氨酸功能化生物相容性块共聚物(mBG)的制备。研究了获得mBG的质粒DNA复合能力及其转染效率。RAFT方法对聚合含有特殊功能组的单体非常有益。

Tags

Methionine Block Copolymer RAFT Polymerization Biocompatible Plasmid DNA Delivery

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