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A New Straightforward Method for Lipophilicity (logP) Measurement using 19F NMR Spectroscopy
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JoVE Journal Chimica
A New Straightforward Method for Lipophilicity (logP) Measurement using 19F NMR Spectroscopy

A New Straightforward Method for Lipophilicity (logP) Measurement using 19F NMR Spectroscopy

DOI:
10.3791/58567-v

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09:32 min

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January 30, 2019

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, , , , ,
1Chimica,University of Southampton, 2Medicinal Chemistry, Oncology, IMED Biotech Unit,AstraZeneca

Capitoli

  • 00:04Titolo
  • 00:54Partitioning and NMR Sample Preparation
  • 03:49NMR Experiments
  • 05:14Data Processing
  • 07:33Results: Method Validation and Selected Examples of logP Measurement
  • 08:48Conclusion

Summary

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A novel and straightforward variation of the shake-flask method was developed for accurate lipophilicity measurement of fluorinated compounds by 19F NMR spectroscopy.

Tags

Keywords: LipophilicityLogP19F NMR SpectroscopyFluorine NMROrganic CompoundsMedicinal ChemistryReference CompoundN-octanolWaterPhase SeparationAliquotNMR Tube

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