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The Galleria mellonella Waxworm Infection Model for Disseminated Candidiasis
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Immunologia e infezioni
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JoVE Journal Immunologia e infezioni
The Galleria mellonella Waxworm Infection Model for Disseminated Candidiasis

The Galleria mellonella Waxworm Infection Model for Disseminated Candidiasis

DOI:
10.3791/58914-v

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07:33 min

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November 17, 2018

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, ,
1Department of Microbiology,The Ohio State University, 2Department of Microbial Infection and Immunity,The Ohio State University

Capitoli

  • 00:04Titolo
  • 00:35Galleria mellonella Waxworm Larvae and Culture Preparation
  • 02:55Galleria mellonella Larvae Infection with Candida Cultures
  • 05:40“Results: The MTLa Allele Promotes C. albicansKilling of G. mellonella“
  • 06:45Conclusion

Summary

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Galleria mellonella serves as an invertebrate model for disseminated candidiasis. Here, we detail the infection protocol and provide supporting data for the model's effectiveness.

Tags

Galleria MellonellaWaxwormDisseminated CandidiasisCandida Infection ModelC. AlbicansYeastVirulenceGene ContributionAnimal-freeRobustFastCheapHigh-throughputYeast-peptone-dextrose BrothPBSCell CountingInfectious DoseCFU

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