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High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
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Chimica
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JoVE Journal Chimica
High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

DOI:
10.3791/58986-v

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10:17 min

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April 23, 2019

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, , , , , , ,
1Department of Chemistry and Chemical Biology,McMaster University, 2Agilent Technologies Inc., 3Seroclinix Corporation

Capitoli

  • 00:04Titolo
  • 01:10Urine Sample Preparation
  • 02:12Capillary Electrophoresis-Time-of-Flight-Mass Spectrometer (CE-TOF-MS) System Setup
  • 04:29CE Injection and Separation Condition Setup
  • 05:31TOF-MS Setup
  • 06:36Data Analysis
  • 07:41Results: Representative High-throughput and Comprehensive Drug Surveillance
  • 09:25Conclusion

Summary

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Here we describe a high-throughput method for comprehensive drug surveillance that allows for the improved resolution and detection of large panels of drugs of abuse and their metabolites, with quality control based on multisegment injection-capillary electrophoresis-mass spectrometry.

Tags

Keywords: High-throughputComprehensiveDrug SurveillanceMultisegment InjectionCapillary ElectrophoresisMass SpectrometryUrine Drug ScreeningTherapeutic Drug MonitoringMetabolite ProfilingTargeted AnalysisNon-targeted AnalysisSample PreparationCapillary ConditioningCE-MS

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