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Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis (NASH) Resolution
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Medicina
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JoVE Journal Medicina
Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis (NASH) Resolution

Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis (NASH) Resolution

DOI:
10.3791/59130-v

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04:14 min

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April 16, 2019

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, , ,
1Cardiovascular, Renal and Metabolic Diseases,MedImmune, 2Laboratory Animal Resources,MedImmune

Capitoli

  • 00:04Titolo
  • 00:46Liver Biopsy
  • 02:24Results: Representative Effects of the Non-alcoholic Steatohepatitis (NASH) Diet on Mouse Liver Inflammation and Steatosis
  • 03:48Conclusion

Summary

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In clinical settings, a liver biopsy is used to assess stages of non-alcoholic steatohepatitis (steatosis, inflammation, hepatocyte ballooning, and fibrosis). Here, we illustrate a survivable liver biopsy in mice which can be used for histological analyses to enable assessment of therapeutic agents in a manner more aligned with clinical trials.

Tags

Survivable Liver BiopsyNon-alcoholic Steatohepatitis (NASH)NASH ResolutionLiver Lobe ExposureAbdominal IncisionAbsorbable Gelatin SpongeAbdominal Wall SutureWound ClosureNASH Scoring

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