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Measuring the Spin-Lattice Relaxation Magnetic Field Dependence of Hyperpolarized [1-13C]pyruvate
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Measuring the Spin-Lattice Relaxation Magnetic Field Dependence of Hyperpolarized [1-13C]pyruvate

Measuring the Spin-Lattice Relaxation Magnetic Field Dependence of Hyperpolarized [1-13C]pyruvate

DOI:
10.3791/59399-v

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11:57 min

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September 13, 2019

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, ,
1Department of Medical Biophysics,Western University, 2Imaging Research Laboratory, Robarts Research Institute,Western University, 3Ontario Institute for Cancer Research

Capitoli

  • 00:04Titolo
  • 00:47Sample Preparation
  • 06:43Relaxometry
  • 09:37Results: Results of Microwave Sweep, Polarization Decay, Curve Fitting to the Relaxation Curve, and NMRD
  • 11:18Conclusion

Summary

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We present a protocol to measure the magnetic field dependence of the spin-lattice relaxation time of 13C-enriched compounds, hyperpolarized by means of dynamic nuclear polarization, using fast field-cycled relaxometry. Specifically, we have demonstrated this with [1-13C]pyruvate, but the protocol could be extended to other hyperpolarized substrates.

Tags

Keywords: HyperpolarizedSpin-lattice RelaxationMagnetic Field DependenceDNPPyruvatePolarizationT1MRIEDTADissolution MediumMicrowave SweepOptimal Frequency

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