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用于筛查绝经后心血管功能障碍的外源雌激素治疗的活体雌激素缺乏小鼠模型

JoVE Journal
Biochimica

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JoVE Journal Biochimica

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

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用于筛查绝经后心血管功能障碍的外源雌激素治疗的活体雌激素缺乏小鼠模型

DOI:

10.3791/59536-v

•

06:18 min

•

August 13, 2019

•

Bing Sun, Yue-zhang Yin, Jing Xiao

¹Institute of Medicinal Plant Development (IMPLAD),Chinese Academy of Medical Sciences & Peking Union Medical College, ²Shandong University of Traditional Chinese Medicine

Capitoli

00:05Titolo
00:52Bilateral Ovariectomy
02:22Body Weight, Total Cholesterol (TC), and Triglyceride (TG) Measurement
03:25Aorta Harvest
04:29Results: Representative Effects of Exogenous Estrogens on OVX Mouse Phenotype and Function
05:46Conclusion

Summary

Traduzione automatica

临床上,更年期妇女雌激素缺乏可能加重脂质紊乱和动脉粥样硬化的发生率。我们通过在apoE-/-小鼠的双背侧切口,通过双边卵巢切除术建立了体内雌激素缺乏模型。小鼠模型适用于绝经后心血管功能障碍的外源雌激素治疗。

Tags

Keywords: Ovariectomy Estrogen Deficiency APOE Knockout Mice Cardiovascular Dysfunction Menopause Arteriosclerosis Exogenous Estrogen Treatments Plasma Cholesterol Triglycerides

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