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A Human Peripheral Blood Mononuclear Cell (PBMC) Engrafted Humanized Xenograft Model for Translational Immuno-oncology (I-O) Research (A Human Peripheral Blood Mononuclear Cell (PBMC) Engrafted Humanized Xenograft Model for Translational Immuno-oncology (I-O) Research (A-O)
JoVE Journal
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JoVE Journal Ricerca sul cancro
A Human Peripheral Blood Mononuclear Cell (PBMC) Engrafted Humanized Xenograft Model for Translational Immuno-oncology (I-O) Research
DOI:

08:17 min

August 15, 2019

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Capitoli

  • 00:04Titolo
  • 00:46Cyclophosphamide Myeloablation and Human Peripheral Blood Mononuclear Cell (PBMC) Transplantation and Tumor Engraftment
  • 02:08Immunohistochemistry (IHC)
  • 04:33In Vivo Efficacy and Pharmacodynamics Analyses
  • 06:08Results: Representative PBMC- and Tumor-Engraftment and Anti-Tumor Antibody Treatment Analysis
  • 07:16Conclusion

Summary

Traduzione automatica

Nous décrivons une cellule mononucléaire périphérique humaine de sang (PBMC) — modèle humanisé basé de souris de xénogreffe pour la recherche translationnelle d'immuno-oncologie. Ce protocole pourrait servir de ligne directrice générale pour établir et caractériser des modèles similaires pour l'évaluation de la thérapie I-O.

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