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小型动物正电子发射断层扫描/计算机断层扫描中的连续血液采样支持动脉输入函数的测量
JoVE Journal
Medicina
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JoVE Journal Medicina
Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
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小型动物正电子发射断层扫描/计算机断层扫描中的连续血液采样支持动脉输入函数的测量

DOI:
10.3791/59701-v

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10:21 min

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August 08, 2019

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, , , , , , , ,
1Institute of Anatomy,Rostock University Medical Center, 2Department of Nuclear Medicine,Rostock University Medical Center, 3Core Facility Multimodal Small Animal Imaging,Rostock University Medical Center, 4Rudolf-Zenker-Institute for Experimental Surgery,Rostock University Medical Center

Capitoli

  • 00:04Titolo
  • 01:05Animal Catheterization
  • 03:31Image Acquisition and Reconstruction
  • 06:41Manual and Online Blood Sampling
  • 08:31Results: Representative Continuous and Manual Blood Sampling Results
  • 09:47Conclusion

Summary

Traduzione automatica

Traduzione automatica

这里描述了在大鼠PET/CT成像期间连续血液采样的协议,用于测量动脉输入功能(AIF)。演示了导管、系统的校准和设置以及血液放射性的数据分析。生成的数据为后续的生物动力学建模提供输入参数。

Tags

Continuous Blood SamplingSmall AnimalPET/CTArterial Input FunctionExtracorporeal Arteriovenous ShuntBiokinetic ModelingCross-calibrationFemoral VeinFemoral ArteryCatheter PlacementMicrosurgery

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