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Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury
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JoVE Journal Neuroscienze
Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury

DOI:
10.3791/60027-v

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05:01 min

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August 16, 2019

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,
1Department of Surgery,Northwestern University

Capitoli

  • 00:04Titolo
  • 00:42Pre-Surgical Preparation
  • 01:24Controlled Cortical Traumatic Brain Injury (TBI) Induction
  • 03:02Surgical Site Closure and Post-Operative Care
  • 03:39Results: Representative Gross, Histologic, and MRI Evaluation of Mouse Brain Tissue After Severe TBI
  • 04:16Conclusion

Summary

Traduzione automatica

Traduzione automatica

Here we describe a protocol for the induction of murine traumatic brain injury via an open-head controlled cortical impact.

Tags

Keywords: Murine ModelControlled Cortical ImpactTraumatic Brain InjuryStereotaxic FrameCraniectomyDura MaterImpactor TipBiomechanical ParametersReproducible Injury

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