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Capitoli
- 00:04Titolo
- 00:58Electrospray-ion Mobility-Mass Spectrometry Analysis
- 03:02Analysis of ESI-IM-MS pH Titration Data
- 06:11Collision Cross-Sections and Computational Methods
- 08:30Results: Reaction Mechanisms and Coordination Sites of the Alternative Methanobactin Complexes
- 10:00Conclusion
Ion Mobility-massespektrometri og molekylære modelleringsteknikker kan karakterisere den selektive metal chelaterende ydeevne af designede metal bindende peptider og kobber bindende peptid methanobactin. Udvikling af nye klasser af metal Chelat peptider vil hjælpe med at føre til terapeutisk for sygdomme forbundet med metal ionfejl balance.
Tags
Ion Mobility-mass SpectrometryIM-MSMetal Ion RecognitionRedox ActivityMetal Binding OligopeptidesMolecular ModelingTertiary StructureMetal CorrelationESI-IM-MSPoly-DL-alanineAlternative MethanobactinPH-dependent RedoxMethyl Binding ReactionProduct IonsStoichiometryProtonation StateConformational StructureMetal Chelating PeptidesTherapeuticsMenkes DiseaseWilson’s DiseaseCancerAlzheimer’s DiseaseNative ESI-IM-MSNegative IonPositive IonAcetic AcidAmmonium HydroxideMass-to-chargeIsotope Pattern
