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Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
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Immunologia e infezioni
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JoVE Journal Immunologia e infezioni
Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

DOI:
10.3791/60315-v

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09:54 min

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December 03, 2019

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, , , , ,
1Institute of Human Virology, School of Medicine,University of Maryland, 2Grupo Inmunovirología, Facultad de Medicina,Universidad de Antioquia

Capitoli

  • 00:04Titolo
  • 00:45Human CD34+ Hematopoietic Stem Cells (HSC) Engraftment of Newborn Mice
  • 04:18Human Peripheral Blood Mononuclear Cell (PBMC) Engraftment of Juvenile Mice
  • 07:29Results: Representative Changes of Viral Load and CD4:CD8 Ratio in huNS -chainnull Mice after HIV Infection and after Anti-retroviral Therapy Introduction
  • 08:41Conclusion

Summary

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Described here are three experimental approaches for studying the dynamics of HIV infection in humanized mice. The first permits the study of chronic infection events, whereas the two latter allows for the study of acute events after primary infection or viral reactivation.

Tags

Keywords: Chronic HIV InfectionAcute HIV InfectionReactivated HIV InfectionHumanized Immunodeficient Mouse ModelsNSG Humanized MiceCD34+ Human Stem CellsHepatic InjectionHIV Pre-clinical Studies

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