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Immunologia e infezioni

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人类免疫缺陷小鼠模型中的慢性、急性和再激活HIV感染

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Immunologia e infezioni

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JoVE Journal Immunologia e infezioni

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

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人类免疫缺陷小鼠模型中的慢性、急性和再激活HIV感染

DOI:

10.3791/60315-v

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09:54 min

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December 03, 2019

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Federico Perdomo-Celis², Sandra Medina-Moreno, Alonso Heredia, Harry Davis, Joseph Bryant, Juan Carlos Zapata

¹Institute of Human Virology, School of Medicine,University of Maryland, ²Grupo Inmunovirología, Facultad de Medicina,Universidad de Antioquia

Capitoli

00:04Titolo
00:45Human CD34⁺ Hematopoietic Stem Cells (HSC) Engraftment of Newborn Mice
04:18Human Peripheral Blood Mononuclear Cell (PBMC) Engraftment of Juvenile Mice
07:29Results: Representative Changes of Viral Load and CD4:CD8 Ratio in huNS -chain^null Mice after HIV Infection and after Anti-retroviral Therapy Introduction
08:41Conclusion

Summary

Traduzione automatica

本文介绍了三种研究人类小鼠HIV感染动态的实验方法。前者允许研究慢性感染事件，而后者允许研究原发感染或病毒重新激活后的急性事件。

Tags

Keywords: Chronic HIV Infection Acute HIV Infection Reactivated HIV Infection Humanized Immunodeficient Mouse Models NSG Humanized Mice CD34+ Human Stem Cells Hepatic Injection HIV Pre-clinical Studies

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