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A Revised Surgical Approach to Induce Endolymphatic Hydrops in the Guinea Pig
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Neuroscienze
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JoVE Journal Neuroscienze
A Revised Surgical Approach to Induce Endolymphatic Hydrops in the Guinea Pig

A Revised Surgical Approach to Induce Endolymphatic Hydrops in the Guinea Pig

DOI:
10.3791/60597-v

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06:05 min

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June 04, 2020

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, , ,
1Department of Otolaryngology, Head and Neck Surgery,Washington University School of Medicine in St. Louis

Capitoli

  • 00:04Introduction
  • 00:33Surgical Preparation
  • 01:49Endolymphatic Hydrops Induction
  • 04:31Results: Representative Effects of Induced Endolymphatic Hydrops on Guinea Pig Auditory Responses
  • 05:23Conclusion

Summary

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This article demonstrates an extradural approach to obliterate the guinea pig endolymphatic sac and injure the endolymphatic duct with a fine pick in order to induce experimental endolymphatic hydrops.

Tags

Endolymphatic HydropsGuinea PigSurgical ApproachCSF LeakPosterior Semicircular CanalSubcutaneous Fluid BolusLactated Ringer’s SolutionPulse OximeterRectal ProbeWarming BlanketCraniectomySigmoid SinusOperculumPetrous Temporal Bone

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