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Cancer Research

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JoVE Journal Cancer Research
Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
 

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression

Article DOI: 10.3791/60644-v • 07:53 min • March 17th, 2020
March 17th, 2020 •
1, 1, 1, 1
1Oncology R&D group, Pfizer Worldwide Research and Development

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An in vitro model system was developed to capture tissue architectural changes during lung squamous carcinoma (LUSC) progression in a 3-dimensional (3D) co-culture with cancer-associated fibroblasts (CAFs). This organoid system provides a unique platform to investigate the roles of diverse tumor cell-intrinsic and extrinsic changes that modulate the tumor phenotype.

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Keywords: 3D Coculture Lung Squamous Cell Carcinoma Tumor-stroma Interactions Tumor Morphology Tumor Progression Basement Membrane Matrix TUM622 Cells Cancer-associated Fibroblasts Drug Treatment
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