/

/

压力过载诱导中度重塑和收缩功能障碍的大鼠模型，而不是过度收缩性心力衰竭

JoVE Journal
Medicina

È necessario avere un abbonamento a JoVE per visualizzare questo. Accedi o inizia la tua prova gratuita.

JoVE Journal Medicina

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure

Please note that all translations are automatically generated. Click here for the English version.

压力过载诱导中度重塑和收缩功能障碍的大鼠模型，而不是过度收缩性心力衰竭

DOI:

10.3791/60954-v

•

07:13 min

•

April 30, 2020

•

Antoine H. Chaanine, L. Gabriel Navar, Patrice Delafontaine^2,3

¹Department of Medicine/Heart and Vascular Institute,Tulane University, ²Department of Physiology,Tulane University, ³Department of Pharmacology,Tulane University

Capitoli

00:04Introduction
00:38Surgical Ascending Aortic Banding (AAB) Procedure Preparation
01:48AAB Procedure
03:10Echocardiography
04:18Results: Representative Pressure Overload-Induced Remodeling and Systolic Dysfunction Analyses
06:37Conclusion

Summary

Traduzione automatica

我们描述了压力过载诱导中度重塑和早期收缩功能障碍的大鼠模型的创建，其中在启动改造过程过程中涉及的信号转导通路被激活。这种动物模型将有助于确定分子靶点，用于应用早期治疗性抗重塑策略治疗心力衰竭。

Tags

Keywords: Rat Model Pressure Overload Cardiac Remodeling Systolic Dysfunction Heart Failure Metabolic Remodeling Myocardial Dysfunction Calcium Cycling Vascular Clip Thoracotomy Echocardiographic Imaging

Article

Embed

AGGIUNGI ALLA PLAYLIST

Usage Statistics

Video correlati

主动脉原位移植大鼠模型，研究慢性血管病变的发展

缺血性心力衰竭在临床前模型的转基因

大鼠建立压力超负荷心肌肥厚模型在升主动脉缩窄

大鼠颈动脉球囊损伤模型试验抗血管重建治疗

分流手术，右心导管，血管形态计量学在大鼠模型中的流量引起的肺动脉高压

心动过速诱发的心肌病作为猪慢性心力衰竭模型的研究

代谢综合征心力衰竭模型大鼠心房心肌细胞的分离与保留射血分数的关系

压力超载诱发右室肥厚和衰竭的肺动脉扣条柱模型

建立干细胞治疗心肌梗塞心力衰竭的猪模型

大鼠中三极重化控制体积过载的图像引导透射斜线阀传单穿刺模型

Read Article