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Neuroscience

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JoVE Journal Neuroscience
Low-intensity Blast Wave Model for Preclinical Assessment of Closed-head Mild Traumatic Brain Injury in Rodents
 

Low-intensity Blast Wave Model for Preclinical Assessment of Closed-head Mild Traumatic Brain Injury in Rodents

Article DOI: 10.3791/61244-v • 06:09 min • November 6th, 2020
November 6th, 2020 •
*1,2, *3, *4, 5, 5, 4, 6, *5, *7
1Geriatrics Research Education and Clinical Center, Veterans Affairs, 2Division of Gerontology and Geriatric Medicine, University of Washington, 3Department of Neurosurgery, University of Florida, 4Department of Neurosurgery, West Virginia University, 5Division of Pharmaceutical Sciences, University of Cincinnati, 6Central Illinois Neuro Health Sciences, Bloomington, IL, 7Neuro-research, Dallas, TX
* These authors contributed equally

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We present here a protocol of a blast wave model for rodents to investigate neurobiological and pathophysiological effects of mild to moderate traumatic brain injury. We established a gas-driven, bench-top setup equipped with pressure sensors allowing for reliable and reproducible generation of blast-induced mild to moderate traumatic brain injury.

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Low-intensity Blast Wave Model Preclinical Assessment Closed-head Mild Traumatic Brain Injury Rodents Non-invasive Brain Injury Sports Injury Blast Exposure Movement Of The Head Acceleration/deceleration Events TBI Sequelae Working Parts Machine Slide Tables Stainless Steel Surface Animal Experiments PVC Pipe Shield Gas Cylinder Safety Regulations Polyester Membrane
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