È necessario avere un abbonamento a JoVE per visualizzare questo. Accedi o inizia la tua prova gratuita.
1Department of Neuroscience,University of Virginia, 2Department of Radiology,Stanford University, 3Department of Neurology,University of Virginia, 4Global Internship Program,Focused Ultrasound Foundation, 5Department of Medicine,University of Virginia, 6Image Guided Therapy, 7Department of Neurosurgery,University of Virginia, 8Center for Brain, Immunology, and Glia,University of Virginia
Capitoli
- 00:00Introduction
- 01:36Animal Preparation
- 02:44PING Procedure
- 05:55MRI/FUS Control Room
- 06:35Targeting of FUS
- 07:07Administration of Microbubble, FUS, and Contrast Age
- 07:47Infusion of Quinolinic Acid
- 08:15Results: Imaging and Microscopy
- 10:03Conclusions for PING Method
Målet med protokollen er at give en metode til fremstilling af ikke-invasive neuronale læsioner i hjernen. Metoden udnytter Magnetic Resonance-guidet Fokuseret ultralyd (MRgFUS) til at åbne Blodhjernen Barrier i en forbigående og fokal måde, for at levere en cirkulerende neurotoksin til hjernen parenkym.
