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A Novel Pavlovian Fear Conditioning Paradigm to Study Freezing and Flight Behavior
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Capitoli
- 00:04Introduction
- 01:01Behavioral Protocol and Video Tracking Setup
- 01:51Behavioral Experiment Setup
- 02:31Pre-Conditioning/Pre-Exposure and Fear Conditioning
- 04:20Fear Recall and Fear Extinction
- 05:13Behavior Quantification
- 07:00Results: Representative Freezing and Flight Behavior Analyses
- 08:49Conclusion
Defensive behavioral responses are contingent upon threat intensity, proximity, and context of exposure. Based on these factors, we developed a classical conditioning paradigm that elicits clear transitions between conditioned freezing and flight behavior within individual subjects. This model is crucial for the understanding the pathologies involved in anxiety, panic, and post-traumatic stress disorders.
