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Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
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Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

DOI:
10.3791/61547-v

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06:35 min

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June 28, 2021

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, , , ,
1Discipline of Clinical Emergencies, Department of Clinical Medicine, HCFMUSP / LIM 51,University of São Paulo Medical School

Capitoli

  • 00:04Introduction
  • 01:07Laparotomy and Exposing the Pancreas
  • 02:17Severe Acute Pancreatitis Induction
  • 03:30Methods for Analysis
  • 05:13Results: Analysis of Histological and Serological Changes after Induction of Acute Pancreatitis
  • 06:00Conclusion

Summary

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Animal models for severe acute pancreatitis enable the study of pathophysiological changes at the initial stage, facilitating observation of the evolution of inflammatory events. Here we provide a protocol for the induction of severe acute biliary pancreatitis by retrograde infusion of sodium taurocholate into the pancreatic duct of anesthetized C57BL/6 mice.

Tags

Keywords: Acute PancreatitisC57BL/6 MiceSodium TaurocholateBiliary PancreatitisInflammatory ResponsePharmacological InterventionLaparotomyCommon Bile DuctDuodenumInfusionAnimal Model

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