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Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination
 

Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination

Article DOI: 10.3791/61593-v • 05:39 min • February 9th, 2021
February 9th, 2021 •
1, 1, 1, 1, 1, 1,2,3
1Respiratory Medicine, Nagoya University Graduate School of Medicine, 2Nagoya University Institute for Advanced Research, 3B3-Unit, Advanced Analytical and Diagnostic Imaging Center (AADIC)/Medical Engineering Unit (MEU), Nagoya University Institute for Advanced Research

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Near-infrared photoimmunotherapy (NIR-PIT) is an emerging cancer therapeutic strategy that utilizes an antibody-photoabsorber (IR700Dye) conjugate and NIR light to destroy cancer cells. Here, we present a method to evaluate the antitumor effect of NIR-PIT in a mouse model of pleural disseminated lung cancer and malignant pleural mesothelioma using bioluminescence imaging.

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Keywords: Near Infrared Photoimmunotherapy Pleural Dissemination Mouse Model Bioluminescence Imaging D-luciferin 690-nanometer Laser Light Dose
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