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Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models
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JoVE Journal Bioingegneria
Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models

DOI:
10.3791/61706-v

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07:56 min

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November 11, 2020

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, ,
1Department of Chemical and Biomolecular Engineering,University of Delaware

Capitoli

  • 00:04Introduction
  • 00:393D Printed Experimental Component Preparation
  • 01:20Lobe Outlet Cap Assembly
  • 02:14Clinically Relevant Air Flow Profile Generation
  • 03:28Aerosol Delivery
  • 05:09Outlet Paper Imaging
  • 05:36Results: Representative Setup Validation and Targeting Experiment Data
  • 07:19Conclusion

Summary

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We present a high-throughput, in vitro method for quantifying regional pulmonary deposition at the lobe level using CT scan-derived, 3D printed lung models with tunable air flow profiles.

Tags

3D Printed Lung ModelsRegional Pulmonary DepositionTargeted Pulmonary TherapeuticsAnatomically Accurate Lung ModelsCT ScansPersonalized Predictive ResultsLung CancerCOPDSoft ResinHard ResinLobe Outlet Cap AssemblyFilter PaperFlow MeterFlow ControllerVacuum Pump

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