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Fabrication of Magnetic Platforms for Micron-Scale Organization of Interconnected Neurons
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JoVE Journal Bioingegneria
Fabrication of Magnetic Platforms for Micron-Scale Organization of Interconnected Neurons

Fabrication of Magnetic Platforms for Micron-Scale Organization of Interconnected Neurons

DOI:
10.3791/62013-v

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09:54 min

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July 14, 2021

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, , , , , , , ,
1Department of Physics,Bar-Ilan University, 2Faculty of Engineering,Bar-Ilan University, 3Department of chemistry,Bar-Ilan University, 4The Institutes of Nanotechnology & Advanced Materials,Bar-Ilan University

Capitoli

  • 00:05Introduction
  • 00:55Magnetic Platform Fabrication
  • 03:06Characterization of Magnetic Device via Transport Measurements
  • 04:00Cellular MNP Uptake and Viability
  • 05:26Cell Differentiation and Growth on Magnetic Platform
  • 07:04Results: MNP-loaded PC12 Cells on Magnetic Devices
  • 09:10Conclusion

Summary

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Traduzione automatica

This work presents a bottom-up approach to the engineering of local magnetic forces for control of neuronal organization. Neuron-like cells loaded with magnetic nanoparticles (MNPs) are plated atop and controlled by a micro-patterned platform with perpendicular magnetization. Also described are magnetic characterization, MNP cellular uptake, cell viability, and statistical analysis.

Tags

Magnetic PlatformsMicron-scale OrganizationInterconnected NeuronsNeural Network FormationMagnetic ManipulationsIn Vitro StudiesBiointerfacing DevicesMagnetic NanoparticlesPhotolithographyFerromagnetic Multilayers

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